Azoxystrobin

Mol. wt. 403.4 M.f. C₂₂H₁₇N₃O₅ Form White solid. M.p. 116 °C (tech., 114-116 °C) V.p. 1.1 ´ 10^-7 mPa (20 °C) K_OW logP = 2.5 (20 °C) Henry 7.3 ´ 10^-9 Pa m³ mol^-1 (calc.) S.g./density 1.34 (20 °C) Solubility In water 6 mg/l (20 ºC). Low solubility in hexane, n-octanol; moderate solubility in methanol, toluene, acetone; high solubility in ethyl acetate, acetonitrile, dichloromethane. Stability DT₅₀ for aqueous photolysis 2 w. Stable to hydrolysis.

USES Azoxystrobin

Uses Controls the following pathogens at application rates between 100 to 375 g/ha: Erysiphe graminis, Puccinia spp., Leptosphaeria nodorum, Septoria tritici and Pyrenophora teres on temperate cereals; Pyricularia oryzae and Rhizoctonia solani on rice; Plasmopara viticola and Uncinula necator on vines; Sphaerotheca fuliginea and Pseudoperonospora cubensis on cucurbitaceae; Phytophthora infestans and Alternaria solani on potato and tomato; Mycosphaerella arachidis, Rhizoctonia solani and Sclerotium rolfsii on peanut; Monilinia spp. and Cladosporium carpophilum on peach; Pythium spp. and Rhizoctonia solani on turf; Mycosphaerella spp. on banana; Cladosporium caryigenum on pecan; Elsino?fawcettii, Colletotrichum spp. and Guignardia citricarpa on citrus; Colletotrichum spp. and Hemileia vastatrix on coffee.

MAMMALIAN TOXICOLOGY Azoxystrobin

Oral Acute oral LD₅₀ for male and female rats and mice >5000 mg/kg. Skin and eye Acute percutaneous LD₅₀ for rats >2000 mg/kg. Slight eye and skin irritation (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC₅₀ for male rats 0.96, female rats 0.69 mg/kg. NOEL 18 mg/kg b.w. daily. ADI 0.1 mg/kg b.w. (EU); 0.18 mg/kg b.w. (USA) Other Not oncogenic in rats or mice. No evidence of neurotoxicity, endocrine effects or teratogenicity. Toxicity class WHO (a.i.) III (Table 5) EC hazard T; R23| N; R50, R53

ECOTOXICOLOGY Azoxystrobin

Birds Acute oral LD₅₀ for mallard ducks and bobwhite quail >2000 mg/kg. Sub-acute dietary LC₅₀ (5 d) for bobwhite quail and mallard ducks >5200 mg/kg diet. Fish LC₅₀ (96 h) for rainbow trout 0.47, bluegill sunfish 1.1, carp 1.6, sheepshead minnow 0.66 mg/l. For degradate R234886, LC₅₀ >150 mg/l. Daphnia EC₅₀ (48 h) 259 mg/l. EC₅₀ for degradates: R234886 >180, R401553 >50, R402173 >50 mg/l. Algae EC₅₀ (120 h) for green algae 0.12 mg/l. Other aquatic spp. LC₅₀ for mysid shrimp 55 mg/l; EC₅₀ for pacific oyster 1300 mg/l, Lemna gibba 3.2 mg/l. Bees LD₅₀ for honeybees >200 mg/bee. Worms LC₅₀ (14 d) for earthworms 283 mg/kg. Other beneficial spp. Harmless to non-target organisms, including predatory mites and bugs, spiders, lacewings, hoverfly, ladybird, carabid beetle, parasitoid wasps and bees, under field conditions at field application rates (IOBC).

ENVIRONMENTAL FATE Azoxystrobin

Animals In rats, the majority of radiolabel is excreted in the faeces, with little remaining radioactivity in any tissues of the animal. A large number of metabolites was formed, of which only the glucuronide of azoxystrobin acid is present at >10% of the administered dose. In goats and hens, azoxystrobin is also excreted rapidly, with low residues in milk, meat or eggs. For details, see R. S. I. Joseph in "Pesticide Chemistry and Bioscience". Plants In wheat, grapes and peanuts, metabolism was extensive, but parent azoxystrobin was the only major (>10%) residue. Metabolism followed similar pathways in all three crops. Soil/Environment Typical DT₅₀ (lab.) 8-12 w. In soil, in the dark, six identified metabolites were formed; over 1 y, 45% of applied radiolabel is evolved as CO₂. Dissipation in the field is faster, DT₅₀ 1-8 w. On soil, photolysis DT₅₀ 11 d. Azoxystrobin and its degradates have low to moderate mobility in soil; typical K_oc for azoxystrobin c. 500. Field dissipation studies showed that neither azoxystrobin nor its major degradates were typically found in soil below the top 15 cm.

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