Fenvalerate

Composition Tech. grade fenvalerate is 92.1% pure. Mol. wt. 419.9 M.f. C₂₅H₂₂ClNO₃ Form Tech. fenvalerate is a viscous yellow or brown liquid, sometimes partly crystalline at room temperature. M.p. 39.5-53.7 °C (pure) B.p. Decomposes on distillation. V.p. 1.92 ´ 10^-2 mPa (20 ºC) K_OW logP = 5.01 (23 ºC) S.g./density 1.175 (25 ºC) Solubility In water <10 mg/l (25 ºC). In n-hexane 53, xylene ³200, methanol 84 (all in g/l, 20 ºC). Stability Stable to heat and moisture. Relatively stable in acidic media, but rapidly hydrolysed in alkaline media. F.p. 230 °C

APPLICATIONS Fenvalerate

Mode of action Non-systemic insecticide and acaricide with contact and stomach action. Uses Control of a wide range of pests, including those resistant to organochlorine, organophosphorus, and carbamate insecticides. Uses include control of chewing, sucking, and boring insects (particularly Lepidoptera, Diptera, Orthoptera, Hemiptera, and Coleoptera) in fruit, vines, olives, hops, nuts, vegetables, cucurbits, cotton, oilseed rape, sunflowers, alfalfa, cereals, maize, sorghum, potatoes, beet, peanuts, soya beans, tobacco, sugar cane, ornamentals, forestry, and on non-crop land. Used for control of flying and crawling insects in public health situations and in animal houses. Also used as an animal ectoparasiticide. Formulation types EC; UL; SC; WP. Compatibility Incompatible with alkaline materials. Selected tradenames: 'Sumicidin' (Sumitomo); 'Arfen' (Ramcides); 'Dufen' (Dhanuka); 'Fenkill' (United Phosphorus); 'Fenny' (Nagarjuna Agrichem); 'Fenval' (RPG); 'Kayvalerate' (Krishi Rasayan); 'Newfen' (Gharda); 'Sanvalerate' (Sanachem); 'Shasicidin' (Sanonda); 'Starfen' (Shaw Wallace); 'Sumitox' (Aimco)

MAMMALIAN TOXICOLOGY Fenvalerate

Reviews FAO/WHO 47 (see part 2 of the Bibliography). See also A. J. Gray & D. M. Soderlund, Chapt. 5 in "Insecticides". IARC ref. 53 class 3 Oral Acute oral LD₅₀ for rats 451 mg/kg. Skin and eye Acute percutaneous LD₅₀ for rabbits 1000-3200, rats >5000 mg/kg. Slightly irritating to skin and eyes (rabbits). Inhalation LC₅₀ for rats >101 mg/m³. NOEL (2 y) for rats 250 mg/kg diet. ADI (JMPR) 0.02 mg/kg b.w. [1986]. Toxicity class WHO (a.i.) II; EPA (formulation) II

ECOTOXICOLOGY Fenvalerate

Birds Acute oral LD₅₀ for domestic fowl >1600, mallard ducks 9932 mg/kg. Dietary LC₅₀ for quail >10 000, mallard ducks 5500 mg/kg. Fish LC₅₀ (96 h) for rainbow trout 0.0036 mg/l. Bees Toxic to bees. Contact LD₅₀ 0.23 mg/bee.

ENVIRONMENTAL FATE Fenvalerate

EHC 95 (WHO, 1990). EHC 95 cites rapid degradation and decomposition, reduced toxicity of its degradation products, and absence of leaching in soil. Although laboratory tests show high toxicity for fish and bees, these effects are markedly reduced under field conditions because of adsorption to sediments, and the compound's strong repellent effect. The report concludes that risks to the environment are unlikely when it is applied as recommended. Animals In mammals, following oral administration, fenvalerate is rapidly metabolised. Up to 96% is excreted in the faeces within 6-14 days. For a study of the metabolism of fenvalerate in the laying hen, see J. Agric. Food Chem., 1989, 37, 190. Plants In plants, fenvalerate is split into two parts by cleavage of the ether group, followed by further hydroxylation in the 2- and 4- positions of the phenoxy ring, and hydrolysis of the nitrile group to amide and carboxyl groups. The majority of the acids and phenols thus formed are converted into glucosides. Soil/Environment In aqueous media, the ester bond is hydrolysed. In light, decarboxylation occurs, with recombination of the cleaved moieties (R. L. Holmstead et al., J. Agric. Food Chem., 1977, 25, 56-58). DT₅₀ in soil c. 75-80 d.

To receive any additional product information, please write to us